Ocular Physiology Lab
- Dr Bang Bui
- Dr Christine Nguyen
- Dr Zheng He
- Ms Vickie Wong
- Ms Tina Tsai
- Mr J Charng
- Ms Flora Hui
- Mr Edward Liu
- Mr Jeremiah Lim
- Ms Rachael O'Connell
- Mr Joseph Paul
- Ms Angelina Duan
National & International Collaborators
- Dr J Armitage – Deakin University, Warn ponds, Australia
- Dr Andreas Fouras -Monash University, Australia
- Dr B Fortune and Dr L Wang - Devers Eye Institute, Portland, USA
- Dr John Morrison - Casey Eye Institute, Portland, USA
- Dr Rachael Gurrell, Ms Rebecca Fish, Neusensis, Cambridge, UK
- Dr M Kalloniatis – Centre for Eye Health, Australia
- Prof J Crowston, Dr I Trounce – Centre for Eye Research Australia, Ophthalmology, University of Melbourne, Australia
- Dr E Fletcher, Dr A Jobling - Department of Anatomy and Cell Biology, University of Melbourne, Australia
- Prof S Hosking – Australian College of Optometry, Australia
Non-invasive function and imaging
The electroretinogram remains the most commonly used measure of retinal integrity. We are applying a range of selective pharmacological tools to isolate inner retinal modulators of the waveform. In addition we hope to separate responses generated by neurons from those arising from non-neuronal elements (epithelia and/or glia). We are currently developing the means to simultaneously record electroretinograms and visual evoked response from awake rats.
Along with our collaborators at Monash and Deakin University and our industry partner we are developing non-invasive imaging approaches for the assessment of blood flow in the eye and brain.
The above electrophysiological and imaging approached are applied as outcomes measures along with non-invasive stress tests to determine the risk factors that predispose eyes to neurodegeneration.
Risk factors for neurodegeneration
There are many inconsistencies in the clinical presentation of glaucoma. One controversy is the role of intraocular pressure elevation. In order to clarify its role, we are assessing the contribution of ocular perfusion pressure to the development of glaucoma, by modulating either intraocular pressure or blood pressure, both independently and in concert.
Age is a risk factor for both glaucoma and diabetes. Whether abnormalities in mitochondria underlie this age related susceptibility is being considered in collaboration with the Centre for Eye Research, Melbourne and St Vincent’s Health, Melbourne. We are also assessing the contribution of age-related changes to blood flow autoregulation in the development of ganglion cell injury.
- Nguyen CT, Vingrys AJ, Bui BV (2012) Dietary omega-3 deficiency and IOP insult are additive risk factors for ganglion cell dysfunction. J Glaucoma. In press.
- He Z, Nguyen CT, Armitage JA, Vingrys AJ, Bui BV (2012) Blood pressure modifies retinal susceptibility to intraocular pressure elevation. PLoS ONE ;7(2):e31104.
- Kong YX, van Bergen N, Bui BV, Chrysostomou V, Vingrys AJ, Trounce IA, Crowston JG (2012) Impact of aging and diet restriction on retinal function during and after acute intraocular pressure injury. Neurobiol Aging. 33:1126.e15-25
- Wong HYV, Vingrys AJ, Bui BV (2011) Glial and neuronal dysfunction in Streptozotocin-induced diabetic rats. J Ocul Biol Dis Inform. 4;42-50.
- Charng J, Nguyen CT, Bui BV, Vingrys AJ (2011) Age-related retinal function changes in albino and pigmented rats. Invest Ophthalmol Vis Sci 52:8891-9.
- Dang TM, Tsai TI, Vingrys AJ, Bui BV (2011) Post-receptoral contributions to the rat scotopic electroretinogram a-wave. Doc Ophthalmol 122:149-56.
- Kong YX, Van Bergen N, Trounce IA, Bui BV, Chrysostomou V, Waugh H, Vingrys A, Crowston JG (2011) Increase in mitochondrial DNA mutations impairs retinal function and renders the retina vulnerable to injury. Aging Cell 10:572-83.
- He Z, Vingrys AJ, Armitage JA, Bui BV (2011) The role of blood pressure in glaucoma. Clin Exp Optom. 94:133-49.
- Wong VH, Bui BV, Vingrys AJ (2011) Clinical and experimental links between diabetes and glaucoma. Clin Exp Optom. 94:4-23.
Dr Bang V Bui
Ph: 8344 7o66
Fx: 9035 9909
Em: bvb@ unimelb.edu.au