Faculty of ScienceDepartment of Optometry & Vision Sciences

Ocular Physiology Lab

Research Team

National & International Collaborators

Non-invasive function and imaging

The electroretinogram remains the most commonly used measure of retinal integrity. We are applying a range of selective pharmacological tools to isolate inner retinal modulators of the waveform. In addition we hope to separate responses generated by neurons from those arising from non-neuronal elements (epithelia and/or glia). We are currently developing the means to simultaneously record electroretinograms and visual evoked response from awake rats.

Along with our collaborators at Monash and Deakin University and our industry partner we are developing non-invasive imaging approaches for the assessment of blood flow in the eye and brain.

The above electrophysiological and imaging approached are applied as outcomes measures along with non-invasive stress tests to determine the risk factors that predispose eyes to neurodegeneration.

Risk factors for neurodegeneration

There are many inconsistencies in the clinical presentation of glaucoma. One controversy is the role of intraocular pressure elevation. In order to clarify its role, we are assessing the contribution of ocular perfusion pressure to the development of glaucoma, by modulating either intraocular pressure or blood pressure, both independently and in concert.

Age is a risk factor for both glaucoma and diabetes. Whether abnormalities in mitochondria underlie this age related susceptibility is being considered in collaboration with the Centre for Eye Research, Melbourne and St Vincent’s Health, Melbourne. We are also assessing the contribution of age-related changes to blood flow autoregulation in the development of ganglion cell injury.

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Recent Publications

Contact:

Dr Bang V Bui
Ph: 8344 7o66
Fx: 9035 9909
Em: bvb@ unimelb.edu.au

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