Ocular Physiology Lab
Research Team
- Dr Bang Bui
- Ms Vickie Wong
- Dr Zheng He
- Ms Tina Tsai
- Dr George Kong
- Mr Daniel Adler
- Mr J Charng
- Ms SE Chin
National & International Collaborators
- Dr J Crowston – Centre for Eye Research Australia, Ophthalmology, University of Melbourne, Australia
- Dr I Trounce - Department of Clinical Neurosciences, St Vincent’s Health, Melbourne
- Dr M Tolcos, Dr M Loeliger and Dr E Fletcher – Department of Anatomy and Cell Biology, University of Melbourne, Australia
- Dr J Armitage – Baker Heart Institute Melbourne, Australia
- Dr Burdon, Dr D Mackey and Dr J Craig – Flinders University, Australia
- Dr J Forte - Department of Psychology, University of Melbourne, Australia
- Dr B Fortune and Dr L Wang - Discoveries in Sight, Portland, USA
- Dr M Kalloniatis – Department of Optometry and Vision Science, Auckland University, NZ
Retinal processing and non-invasive test for early disease detection
The electroretinogram remains the most commonly used measure of retinal integrity. We are applying a range of selective pharmacological tools to isolate inner retinal modulators of the waveform. In addition we hope to separate responses generated by neurons from those arising from non-neuronal elements (epithelia and/or glia).
Risk factors for neurodegeneration
There are many inconsistencies in the clinical presentation of glaucoma. One controversy is the role of intraocular pressure elevation. In order to clarify its role, we are assessing the contribution of ocular perfusion pressure to the development of glaucoma, by modulating either intraocular pressure or blood pressure, both independently and in concert. We also hope to clarify the role of repeated intraocular pressure “spikes” on ganglion cell integrity.
Age is a risk factor for both glaucoma and diabetes. Abnormalities in mitochondria may underlie this age related susceptibility. This is the subject of a new project in conjunction with the Centre for Eye Research, Melbourne and St Vincent’s Health, Melbourne. We are also considering the role of anaemia in diabetic pathophysiology. Finally, the presence of ganglion cell dysfunction in diabetes and the role of diabetes in predisposing to glaucoma will also be assessed.
top of pageRecent Publications
- Kozaki, K., Vingrys, A.J., Bui, B.V. (2008). Early inner retinal dysfunction in streptozotocin induced diabetic rats. Invest Ophthalmol Vis Sci. 49:3595-604.
- Nguyen, C.T.O., Vingrys, A.J., Bui, B.V. (2008). Dietary omega-3 fatty acids modify ganglion cell function. Invest Ophthalmol Vis Sci. 49:3586-94.
- Forte, J.D., Bui, B.V., Vingrys, A.J. (2008). Wavelet analysis reveals dynamics of rat oscillatory potentials. J Neurosci Methods 169:191-200.
- He, Z., Bui, B.V., Vingrys, A.J. (2008). Effect of repeated IOP challenge on rat retinal function. Invest Ophthalmol Vis Sci. 49:3026-34.
- Sun, D., Bui, B.V., Vingrys, A.J., Kalloniatis, M. (2007) Alterations in photoreceptor-bipolar cell signalling following ischaemia/reperfusion in the rat retina. J Comp Neurol. 505:131-146.
- Berkowitz, B.A., Roberts, R., Luan, H., Bissig, D., Bui, B.V., Vingrys, A.J., Gradianu, M. (2007) Manganese-enhanced MRI Studies of Alterations of Intraretinal Ion Demand in Models of Ocular Injury. Invest Ophthalmol Vis Sci. 48:3796-3804.
- Nguyen, C.T.O., Bui, B.V., Sinclair, A.J., Vingrys, A.J. (2007) Dietary omega 3 fatty acids decrease intraocular pressure with age by increasing aqueous outflow. Invest Ophthalmol Vis Sci. 48:756-762.
- He, Z., Bui, B.V., Vingrys, A.J. (2006) The rate of functional recovery from acute IOP elevation. Invest Ophthalmol Vis Sci. 47:4872-4880.
Contact:
Dr Bang V Bui
Ph: 9349 7521
Fx: 9349 7498
Em:
bvb@ unimelb.edu.au